Griffith University NCNED Makes Breakthrough in ME/CFS Research

pics of the research team outside and in the lab plus shots of logo lit up on the building for CFS Awareness week.711083, Professor Sonya Marshall Gradisnik, Professor Don Staines images for Louise Durack, OMC

As recently reported in the news by SBS and the Huffington Post researchers Professor Sonya Marshall-Gradisnik and Professor Donald Staines and co-workers at the National Centre for Neuroimmunology and Emerging Diseases (NCNED) at Griffith University have made a breakthrough in ME/CFS research. They have found strong evidence for immune dysfunction. They have identified a defective cell receptor that appears to be central to the development of ME/CFS.

This work gives all with ME/CFS some hope that there may be targets in the future for diagnosis and possibly drug treatments.

 

(Post Author’s Note: I personally find it insulting that Queensland’s Science Minister should say (while well-intentioned), referring to this discovery and ME/CFS: “…that it is a ‘real’ illness – not a psychological issue…”. My question for the Minister is: since when are psychological illnesses not real?)

Recent Publications from NCNED

NCNED Newsletter September 2016 (PDF, 476kb)

Nguyen, T., et al. “Impaired calcium mobilization in natural killer cells from chronic fatigue syndrome/myalgic encephalomyelitis patients is associated with transient receptor potential melastatin 3 ion channels.” Clin Exp Immunol, 2017, 187(2): 284-293.

Campagnolo, N., et al. “Dietary and nutrition interventions for the therapeutic treatment of chronic fatigue syndrome/myalgic encephalomyelitis: a systematic review.” J Hum Nutr Diet, 2017.

Shan, Z. Y., et al. “Progressive brain changes in patients with chronic fatigue syndrome: A longitudinal MRI study.” J Magn Reson Imaging, 2016.

Johnston, S., et al. “A targeted genome association study examining transient receptor potential ion channels, acetylcholine receptors, and adrenergic receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.” BMC Med Genet, 2016, 17(1): 79.

Marshall-Gradisnik, S., et al. “Single nucleotide polymorphisms and genotypes of transient receptor potential ion channel and acetylcholine receptor genes from isolated B lymphocytes in myalgic encephalomyelitis/chronic fatigue syndrome patients.” J Int Med Res, 2016.

Chacko, A., et al. “Dysregulation of Protein Kinase Gene Expression in NK Cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients.” Gene Regul Syst Bio, 2016, 10: 85-93.

Nguyen, T., et al. “Novel identification and characterisation of Transient receptor potential melastatin 3 ion channels on Natural Killer cells and B lymphocytes: effects on cell signalling in Chronic fatigue syndrome/Myalgic encephalomyelitis patients.” Biol Res, 2016, 49(1): 27.

Huth, T. K., et al. “Killer Cell Immunoglobulin-like Receptor Genotype and Haplotype Investigation of Natural Killer Cells from an Australian Population of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients.” Gene Regul Syst Bio, 2016, 10: 43-49.

Johnston, S. C., et al. “Epidemiological characteristics of chronic fatigue syndrome/myalgic encephalomyelitis in Australian patients.” Clin Epidemiol, 2016, 8: 97-107.

Nguyen, T., et al. “Novel characterisation of mast cell phenotypes from peripheral blood mononuclear cells in chronic fatigue syndrome/myalgic encephalomyelitis patients.” Asian Pac J Allergy Immunol, 2016.

Collatz, A., et al. “A Systematic Review of Drug Therapies for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.” Clin. Ther., 2016, 38(6): 1263-1271.e1269.

Marshall-Gradisnik, S., et al. “Natural killer cells and single nucleotide polymorphisms of specific ion channels and receptor genes in myalgic encephalomyelitis/chronic fatigue syndrome.” Appl Clin Genet, 2016, 9: 39-47.

Ramos, S., et al. “Regulatory T, natural killer T and γδ T cells in multiple sclerosis and chronic fatigue syndrome/myalgic encephalomyelitis: a comparison.” Asian Pac J Allergy Immunol, 2016, 34(4): 300-305.

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