As recently reported in the news by SBS and the Huffington Post researchers Professor Sonya Marshall-Gradisnik and Professor Donald Staines and co-workers at the National Centre for Neuroimmunology and Emerging Diseases (NCNED) at Griffith University have made a breakthrough in ME/CFS research. They have found strong evidence for immune dysfunction. They have identified a defective cell receptor that appears to be central to the development of ME/CFS.
This work gives all with ME/CFS some hope that there may be targets in the future for diagnosis and possibly drug treatments.
(Post Author’s Note: I personally find it insulting that Queensland’s Science Minister should say (while well-intentioned), referring to this discovery and ME/CFS: “…that it is a ‘real’ illness – not a psychological issue…”. My question for the Minister is: since when are psychological illnesses not real?)
Recent Publications from NCNED
Nguyen, T., et al. “Impaired calcium mobilization in natural killer cells from chronic fatigue syndrome/myalgic encephalomyelitis patients is associated with transient receptor potential melastatin 3 ion channels.” Clin Exp Immunol, 2017, 187(2): 284-293.
Campagnolo, N., et al. “Dietary and nutrition interventions for the therapeutic treatment of chronic fatigue syndrome/myalgic encephalomyelitis: a systematic review.” J Hum Nutr Diet, 2017.
Shan, Z. Y., et al. “Progressive brain changes in patients with chronic fatigue syndrome: A longitudinal MRI study.” J Magn Reson Imaging, 2016.
Johnston, S., et al. “A targeted genome association study examining transient receptor potential ion channels, acetylcholine receptors, and adrenergic receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.” BMC Med Genet, 2016, 17(1): 79.
Marshall-Gradisnik, S., et al. “Single nucleotide polymorphisms and genotypes of transient receptor potential ion channel and acetylcholine receptor genes from isolated B lymphocytes in myalgic encephalomyelitis/chronic fatigue syndrome patients.” J Int Med Res, 2016.
Chacko, A., et al. “Dysregulation of Protein Kinase Gene Expression in NK Cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients.” Gene Regul Syst Bio, 2016, 10: 85-93.
Nguyen, T., et al. “Novel identification and characterisation of Transient receptor potential melastatin 3 ion channels on Natural Killer cells and B lymphocytes: effects on cell signalling in Chronic fatigue syndrome/Myalgic encephalomyelitis patients.” Biol Res, 2016, 49(1): 27.
Huth, T. K., et al. “Killer Cell Immunoglobulin-like Receptor Genotype and Haplotype Investigation of Natural Killer Cells from an Australian Population of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients.” Gene Regul Syst Bio, 2016, 10: 43-49.
Johnston, S. C., et al. “Epidemiological characteristics of chronic fatigue syndrome/myalgic encephalomyelitis in Australian patients.” Clin Epidemiol, 2016, 8: 97-107.
Nguyen, T., et al. “Novel characterisation of mast cell phenotypes from peripheral blood mononuclear cells in chronic fatigue syndrome/myalgic encephalomyelitis patients.” Asian Pac J Allergy Immunol, 2016.
Collatz, A., et al. “A Systematic Review of Drug Therapies for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.” Clin. Ther., 2016, 38(6): 1263-1271.e1269.
Marshall-Gradisnik, S., et al. “Natural killer cells and single nucleotide polymorphisms of specific ion channels and receptor genes in myalgic encephalomyelitis/chronic fatigue syndrome.” Appl Clin Genet, 2016, 9: 39-47.
Ramos, S., et al. “Regulatory T, natural killer T and γδ T cells in multiple sclerosis and chronic fatigue syndrome/myalgic encephalomyelitis: a comparison.” Asian Pac J Allergy Immunol, 2016, 34(4): 300-305.