Our Research Digests

Welcome to the 51st edition of the Research Digest featuring a study aimed at identifying possible epidemiological and/or clinical factors that could be associated with PEM severity and a UK study into the factors that influence the frequency of GP visits by patients with ME/CFS.

Welcome to the 50th edition of the Research Digest! This edition features a study comparing subjective and objective measures of physical activity in ME/CFS patients and a study that measured and assessed factors that impact on health-related quality-of-life measures in adolescents.

Welcome to the 49th edition of the Research Digest featuring a study investigating the role that Human herpesvirus 6A may play in ME/CFS pathogenesis and an Australian literature review on metabolomic dysregulation in ME/CFS.

Welcome to the 48th edition of the Research Digest featuring a study that investigates differences in immune gene SNP expression in ME/CFS and a systematic review on neurological impairments as measured by neuroimaging techniques.

Welcome to the 47th edition of the Research Digest. This fortnight’s edition digests a whole brain MRS study looking at metabolite abnormalities in the brains of ME/CFS patients and a French study investigating muscle excitability in exercising and resting muscles of patients diagnosed with ME/CFS.

Welcome to the 46th edition of the Research Digest. This fortnight’s edition features an Australian study examining qualitative feedback from paediatric ME/CFS patients and a study investigating the correlation between ME/CFS disease severity and cellular bioenergetic function.

Welcome to the 45th edition of the Research Digest. This edition features a Norwegian study into the human leukocyte antigen associations in ME/CFS and a Brazilian study into the expression of human endogenous retroviruses in ME/CFS patient blood samples.

Welcome to the 44th edition of the Research Digest. This edition features a recently published book that highlights the value of biomedical research in ME/CFS and a systematic review into the effect of treatment interventions on pain scores in paediatric ME/CFS patients.

Welcome to the 43rd edition of the Research Digest. This fortnight’s edition features two studies that investigate new approaches to the way ME/CFS can be diagnosed using microRNA analysis and fMRI.

Welcome to the 42nd edition, featuring a study into a potential clinically-suitable diagnostic biomarker for ME/CFS and a study that furthers our knowledge of the mitochondrial dysfunction exhibited by ME/CFS patients.

Welcome to the 41st edition, featuring a Doppler study that confirms a reduction in cerebral blood flow in ME/CFS patients & an Australian study that looks at the levels of parasympathetic activity during sleep.

Welcome to the 40th edition, featuring an American metabolomics study of patient plasma and a study looking at the prevalence of paediatric ME/CFS in Chicago according to diverse community-based random sample.

Welcome to the 39th edition, featuring a systematic review of ME/CFS randomized controlled trials and a study into the use of heart rate variability as a non-invasive biomarker for predicting fatigue severity in ME/CFS patients.

Welcome to the 38th edition, featuring a Nature paper examining blood lactate levels in ME/CFS patients whilst at rest and a paper investigating the effect of pharmaceutical intervention on NK cell cytotoxicity in ME/CFS patients compared to healthy individuals.

Welcome to the 37th edition, featuring a retrospective study on the effectiveness of using low-dose naltrexone on ME/CFS patients, and a meta-analysis comparing protein biomarkers of inflammation between ME/CFS patients and non-affected controls.

Welcome to the 36th edition, featuring research looking at altered cardiac autonomic regulation in ME/CFS patients, an analysis of risk factors for ME/CFS and a systematic review of natural killer cells and cytotoxic function in ME/CFS.

Welcome to the 35th edition, featuring an article that examines the results of the controversial PACE trial and offers an alternative clinical approach for practitioners working with patients with ME/CFS, and a paper from NCNED suggesting a potential pharmaco-therapeutic intervention for ME/CFS.

Welcome to the 34th edition, featuring an editorial on the advances in ME/CFS research and clinical care, and a Cochrane amended review of the effectiveness of graded exercise therapy.

Welcome to the 33rd edition, featuring pathophysiological insights to therapeutic opportunities, and an article on work rehabilitation and medical retirement for people with ME/CFS.

Welcome to the 32nd edition, featuring a systemic review of cytokines in ME/CFS and exertion tolerance disease, and an announcement about federal agency funding for research of ME/CFS.

Welcome to the 31st edition, featuring an editorial on the advances in ME/CFS research and clinical care, and a Cochrane amended review of the effectiveness of graded exercise therapy.

Welcome to the 30th edition, featuring articles on mitochondrial alterations in NK lymphocytes from ME/CFS patients, and ME/CFS being induced in repeated forced swimming in mice.

Welcome to the 29th edition, featuring an article on rethinking ME/CFS diagnostic reference intervals via machine learning and the utility of activin B for defining symptom severity, and pathological mechanisms underlying ME/CFS.

Welcome to the 28th edition, featuring articles on post-exertional malaise associated with hypermetabolism, hypoacetylation and purine metabolism deregulation in ME/CFS cases, and advances in understanding the pathophysiology of chronic fatigue syndrome.

Welcome to the 27th edition, featuring an article on monitoring treatment harm in ME/CFS, and innovation in assistive technology.

Welcome to the 26th edition, featuring an article on resting-state functional connectivity, cognition and fatigue, in response to cognitive exertion, and one on patients with chronic fatigue syndrome showing increased hsCRP.

Welcome to the 25th edition, featuring an article on abnormal blood lactate accumulation during repeated exercise testing in ME/CFS, and a study on orthostatic intolerance in CFS.

Welcome to the 24th edition, featuring a pilot study on the genetic predisposition for immune system, hormone, and metabolic dysfunction in ME/CFS, and an article on Epstein-Barr virus dUTPase inducing neuroinflammatory mediators and the implications for ME/CFS.

Welcome to the 23rd edition, featuring articles on the validation of impaired transient receptor potential melastatin 3 ion channel activity in natural killer cells from ME/CFS patients, and markers of non-coeliac wheat sensitivity in patients with ME/CFS.

Welcome to the 22nd edition, featuring an article on a nanoelectronics-blood-based diagnostic biomarker for ME/CFS, and a paper on the ‘cognitive behavioural model’ of chronic fatigue syndrome: Critique of a flawed model.