This month’s Research Digest (#127) highlights Australian-led research advancing our understanding of ME/CFS across quality of life and biology. A longitudinal study shows a persistent and substantial illness burden, with little change in symptoms or functioning over time and ongoing challenges accessing support. Complementary multi-omics and genetic studies point to disruptions in energy metabolism, immune

The 126th edition of the Research Digest brings together clinical, biological, and lived-experience perspectives to strengthen our understanding of long COVID and its overlap with ME/CFS. The featured studies explore emerging diagnostic tools, long-term immune responses, and important biological differences between males and females, highlighting both progress and ongoing gaps. These insights are helping refine how

Welcome to the 125th edition of the Research Digest. This month’s collection reflects the continued strengthening of the evidence base across ME/CFS and related conditions, spanning biological mechanisms, lived experience, and illness trajectories. Together, the featured work reinforces the complex, multisystem nature of ME/CFS, the significant impacts on those most severely affected, and the growing

This month’s Research Digest highlights the breadth of ME/CFS research, spanning biological mechanisms, clinical assessment, diagnostic inequities, and care for people with severe illness. The featured studies examine potential biomarkers of illness severity, the impact of autonomic dysfunction, disparities in diagnosis, and outcomes from specialised care. Together, these findings reinforce ME/CFS as a complex, multi-system condition and

The 123rd edition of the Research Digest highlights advances across theory, care, treatment and biology in long COVID and ME/CFS. A new model suggests that chronic inflammation, immune dysregulation and autonomic imbalance together underpin the complexity of Long COVID. A qualitative study reveals that incorporating lived-experience experts can enhance clinicians’ understanding of PAIS and enhance

Welcome to the 122nd edition of the Research Digest. This month’s studies continue to advance understanding of ME/CFS, highlighting biological differences between post-infectious and gradual-onset ME/CFS, uncovering new insights into how extracellular vesicles may drive post-exertional malaise (PEM), and exploring brain metabolism changes following exercise. We also feature a large international survey on patient-reported treatment outcomes

Welcome to the 121st edition of the Research Digest. In this issue, we explore new research into the neurological and genetic underpinnings of ME/CFS and long COVID, including links to neurodegeneration and neuropsychiatric conditions. We also share findings on the effectiveness of telehealth for homebound individuals, and an Australian study highlighting the profound impact of

The 120th edition of the Research Digest brings together recent research exploring ME/CFS, long COVID, fibromyalgia, and post-viral conditions. The articles included highlight advances in understanding the biological, genetic, and immunological factors underlying these illnesses, as well as potential markers for diagnosis and severity. Together, they provide a snapshot of current developments and emerging insights

This month’s Research Digest highlights new studies advancing our understanding of ME/CFS, long COVID, and related conditions. An Australian POTS study reveals that women experience more severe symptoms and longer diagnostic delays than men. A long COVID Belgian study links severe fatigue symptoms with signs of accelerated ageing and cardiac involvement, while a Harvard-led analysis

This month’s edition of the Research Digest highlights new biomedical findings on ME/CFS and long COVID, with a focus on immune dysfunction, autoimmunity, and potential biomarkers. Studies reveal shared pathways between the two conditions, including elevated autoantibodies and interferon activity. Research into B-cell receptors and BH4 metabolism adds to our understanding of immune and cardiovascular

In this month’s 117th edition of the Research Digest, we explore advancements in the understanding and diagnosis of post-viral conditions, including long COVID and ME/CFS. Highlights include a new algorithm to improve long COVID diagnosis across diverse populations, a comparison of cognitive challenges in ME/CFS and multiple sclerosis, and promising insights from tryptophan metabolism research.

Welcome to the 116th edition of the Research Digest! In this issue, we explore emerging blood-based biomarkers for ME/CFS and share findings from a study highlighting the high burden of chronic overlapping pain conditions and their impact on health and quality of life. From the long COVID field, new research links persistent spike protein in